منابع مشابه
CaMKII inhibition: breaking the cycle of electrical storm?
Electrical storm (ES), a medical emergency, is the frequent occurrence of ventricular tachycardia or fibrillation, defined as 3 or more episodes in a 24-hour period. Although ES can occur in a variety of settings, including ischemia, heart failure, and channelopathies, general incidence and awareness of this condition have dramatically risen since the advent of automatic internal cardiac defibr...
متن کاملEditorial CaMKII Inhibition Breaking the Cycle of Electrical Storm ?
Electrical storm (ES), a medical emergency, is the frequent occurrence of ventricular tachycardia or fibrillation, defined as 3 or more episodes in a 24-hour period. Although ES can occur in a variety of settings, including ischemia, heart failure, and channelopathies, general incidence and awareness of this condition have dramatically risen since the advent of automatic internal cardiac defibr...
متن کاملPersistent reversal of enhanced amphetamine intake by transient CaMKII inhibition.
Amphetamine exposure transiently increases Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) α expression in the nucleus accumbens (NAcc) shell and this persistently increases local GluA1 S831 phosphorylation and enhances behavioral responding to the drug. Here we assessed whether transiently interfering with CaMKII signaling using a dominant-negative CaMKIIα mutant delivered to the NAcc s...
متن کاملCaMKII inhibition in heart failure makes jump to human.
In this issue of Circulation Research, Sossalla et al1 show that acute inhibition of Ca /calmodulin-dependent protein kinase (CaMK)II in failing human myocardium causes functional improvement in contractility by restoring a positive force–frequency relationship (FFR) in cardiac trabeculae. The loss of this normal positive FFR (and often an induction of a negative FFR) is a functional hallmark o...
متن کاملModels of CaMKII Activation
Models of CaMKII activation Calcium/calmodulin-dependent Kinase Type II (CaMKII) is a Ca-activated enzyme that is highly abundant in the brain. It is central to the regulation of glutamatergic synapses and necessary for the induction of long-term potentiation (LTP), an activity-dependent strengthening of synapses that is thought to be the basis for some forms of learning and memory. CaMKII is a...
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ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.031682